Silicone Based Nanocomposite for Treatment of Hydrocephalus

摘要

The effective and enhanced antimicrobial activity of silver-clay nanohybrid structure is attributed to the large surface area and homogeneous dispersion of silver nanoparticles on clay platelets. Based on preliminary studies, we have developed a longer lasting solution to significantly reduce both cell growth and bacterial infection. The approach to reduce bacterial colonization involves the incorporation of novel silver-based nanoclay in silicone in a manner to obtain higher antimicrobial efficiency and homogenous protection of silicone shunt surface. On the other hand, to reduce growth, impregnate silicone with antiproliferative paclitaxel. The unique and controlled antimicrobial properties of silver-clay nanohybrid and antiproliferative characteristic of paclitaxel would make them ideal materials in silicone for dual-action of effectively reducing infection and cell growth.