Development and Characterization of a High-Throughput Screening Surface Combining Geometric and Nanotopographical Mechanical Cues to Investigate Cell-Surface Interactions

摘要

We demonstrate the successful fabrication of a transparent, HTS surface that combines geometric micropatterns and nanotopographical mechanical cues. We have shown that the mechanical cues of these screening surfaces significantly affect the cytoskeleton and FA complexes of hTERT cells depending on the underlying nanotopography. We are currently exploring the response of hMSCs to the array of combined mechanical cues on the fabricated screening surfaces.