Development of Automated Loom for Woven Tissue Engineering Test Systems

摘要

From the results gathered through cell attachment / affinity studies of multiple mesh constructions, it can be concluded that the automated loom is able to create woven tissue engineering scaffolds with variable properties for in vitro study. The ability to vary material composition will lead to the ability to tailor tissue engineering meshes to specific anatomical locations, targeting specific mechanical properties or degradation rates. Manipulation of weave configuration will lead to the ability to affect pore size, fluid transport, and the amount of material in the construct. All of these variables have been shown to affect biologic response in vivo. Quantitative techniques to compare cell attachment should be employed in the future to more closely compare specific combinations and eliminate the ambiguity of assessment via qualitative fluorescence.