An ocular iontophoretic device for local drug delivery using pedot electrode

摘要

An ocular iontophoretic device using biocompatible planar PEDOT electrode is reported. In vivo experiments on rabbit eyes demonstrated the device can realize ocular iontophoresis effectively, simply and conveniently. Compared to conventional eye cups, it can be placed under the eyelid and delivery ions through the settled small part on the eyeball, reducing tissue damage during ion penetration. Devices in different sizes were fabricated for different cases. The highest iontophoretic efficiency in in vivo experiments was 396 ng/mL, while the controlled without iontophoresis one was only 2.69 ng/mL. The efficiency was related to the current, work time and solvent water content.