Cross-modal Consistency of Epileptogenic Network in SEEG and Resting-state fMRI

摘要

Electrophysiological recording and metabolic imaging are two complimentary techniques in preoperative evaluation of epilepsy surgery. High frequency electrical brain activity has been increasingly used in localizing seizure onset zone (SOZ) owing to the development of stereo-EEG (SEEG) technique. However, SEEG recording has no capacity of whole brain coverage as functional MRI. In this study, we performed cross-modal validation of epileptogenic network defined by SEEG and that by resting-state fMRI on individual brain of epilepsy patients. Epileptogenicity index (EI) based on abnormal high frequency SEEG signals was employed to define the epileptogenic network in electrophysiology. Meanwhile, taking the SEEG sites with highest EI as the seed, resting-state functional MRI and connectivity analysis were used to define the epileptogenic network in hemodynamics. The spatial consistency of these two networks was measured by ROC, and the average AUC reached 0.87, which proved a good consistency between electrophysiological and hemodynamic networks in epileptic brain. The difference part in resting-state fMRI network may supplement the SEEG electrode coverage, to reveal more information about epileptic network.