OBSERVATION OF TIME EVOLUTIONARY PHYSICOCHEMICAL PROPERTY OF SILICA NANOPARTICLES AS CRM CANDIDATES

摘要

The necessity for the synthesis of nanomaterials (NMs) with well-controlled physicochemical properties is emerging with the development of nano-industry and advanced applications of nanomaterials in biomedical fields. In this study, we observed time evolution of physicochemical properties of silica nanoparticles (SiO_2 NPs) as candidates of certified reference materials (CRM) for size analysis. We have validated the size stability of spherical SiO_2 NPs exhibiting diameters of 30 and 40 nm in diameter for one year.