Bone response to bone substitute materials: morphology and gene expression

摘要

Novel, synthetic α-tricalcium phosphate and octacalcium phosphate bone substitute and clinically used, anorganic bovine bone substitute revealed similar bone-promoting effects in rat trabecular bone defects. The morphological and gene expression data confirm and extend previous studies showing that the bovine substitute is highly osteoconductive and has a low resorption rate. Since the synthetic, bone substitute promoted a greater initial bone regeneration, this material may provide new, advantageous properties.