Influence of the interconnected macroporous architecture on osteoblastic mineralization of HA bioceramics

摘要

This technology allowed to easily adapt the porous architecture of the material to obtain controlled dimensions (diameter and interconnection size). The influence of the macrostructure (pore diameter from 200 m to 600m) on the in vitro bioactivity of the obtained bioceramics was also examined. The cellular penetration was the same for all types of samples, and reached the third row of pores. The macropore size in the applied experimental conditions did not appear to influence cell invasion. But the quality of the ossicles was significantly for samples which macropores were the largest (400-600m). This phenomenon could be explained, in the case of large diameter, for a better replacement of culture media.