Elongated cell morphology and uniaxial mechanical loading contribute to tenocyte microenvironmental niche

摘要

Elongated morphology and paralleled uniaxial mechanical loading could up-regulate the expression of tenomodulin (phenotype marker for tenocytes) and collagenⅠ (functional molecule), and thus are considered as the niche factors to maintain tenocytes phenotype and to engineer tendon like tissue in vivo.