Collagen/chondroitin sulfate/hyaluronic acid interpenetrating polymer network hydrogels for cartilage tissue engineering

摘要

The IPN CCH hydrogels prepared by collagen self-assembly and self-crosslinked polymerization of CSMA/HAMA possessed better mechanical properties, slower degradation and denser network structures compared to S-CCH hydrogel. The biophysical properties of IPN CCH hydrogels could be modulated by altering the DS of CSMA. The IPN CCH hydrogels had no obvious cytotoxicity and could maintain chondrocytic phenotype, thus had potential application in cartilage tissue engineering.