New Nuclease-Resistant Immunostimulatory Phosphodiester-based Oligonucleotides for Immune Therapies

摘要

The purpose of this study was to develop safe and effective CpG ODNs consisting only of PD backbone for hTLR9 activation. Our data indicate that the number of CpG core motifs strongly influence their potential as hTLR9 agonists. In particular, CpG ODNs with linked PD-ODN2006 sequences can act as effective and potentially safe agonists of hTLR9 at low concentrations. We propose these CpG ODNs consisting of only a PD backbone as a novel class of CpG ODN.