It is possible to measure the concentration of several ions in parallel, indicating the feasibility of the proposed sensors and the potential for their successful use in cells. Though fluorescence based sensing with particle based carriers has been described in the past we believe that the introduction of a QD barcode to capsules with two walls adds an important feature which allows for multiplexed measurements and thus for detecting several ions in parallel. Intracellular sensing in the lysosome for H~+ has been demonstrated with capsules. Delivery of different types of capsules to the cytosol of cells and their multiplexed detection remains a challenge for the future.
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