Pharmacophore Mapping and Virtual Screening Based on the Cochicine Binding Site for Hit Identification

摘要

@@ Pharmacophores have been widespread use in medicinal chemistry for hit and lead identification and during the subsequent lead optimization. The most important consideration is to find novel chemotype hits that provide us a new direction for a project to explore. By using the software Discovery Studio 2.5, we tried to build a pharmacophore model based on the cochicine binding site.