In Vitro Osseogenesis at the Bone-Implant Interface Under Cyclic Tensile and Compressive Strains

摘要

Tensile and compressive strains affect osteoblastprecursors differently. Compressive strains elicit little response while tensile strains induced differentiation. Previous studies have shown similar trends in DNA and ALP expression after cyclic tensile straining, but comparing different experiments is difficult due to varying cell lines, loading conditions, and experimental time points. Future work will examine the responses of osteoclast-like cells, RAW264.7, to the conditioned media of the strained W-20-17 cells. Understanding the close nit relationship between osteoblasts and osteoclasts at the bone-implant interface may allow us to improve implant osseointegration and build better, longer lasting implants in the future.