Proteomic analysis of protein adsorption onto a degradable-polar/hydrophobic/ionic polyurethane

摘要

D-PHI films had greater protein adsorption (~3x greater) as compared to PLGA and TCPS surfaces. Several of the proteins identified by 2-DE and MS analysis may have important implications in understanding the previously observed response (anti-inflammatory) of monocytes to D-PHI when compared to other biomaterial surfaces [4]. Proteins identified that are known to influence monocyte phenotype will be assessed for their protein adsorption to D-PHI, PLGA and TCPS surfaces as well as for their influence on monocyte phenotype in order to better understand why D-PHI exhibits a unique non-inflammatory state when interacting with monocytes, in comparison to PLGA and TCPS.