Mechanisms of Ethylene Oxide/Propylene Oxide Block Copolymer Absorption in Nanoparticle Stabilization for a Poorly Water Soluble Compound

摘要

The aim of this work is to determine the roles of block copolymers in nanoparticle stabilization by analyzing the electrokinetic behavior as a function of the number of ethylene oxide units per copolymer. Using poloxamer with ethylyene oxide units ranging from 26 to 133 as stabilizers, the role of stabilizers was studied and the stabilization mechanisms were elucidated based on the length of ethylene oxide in block copolymers and the concentration of the polymer.