Simultaneous immobilisation of bioactives during 3D powder printing of bioceramic drug release matrices

摘要

The combination of high spatial resolution bioceramic scaffolds and drug delivery systems in one fabrication step by a multicolour 3D printing is beneficial for the reconstruction of bone defects by creating macroporous and microstructured patient specific implants inducing specific biological reactions. In this work we showed that drug localization within low temperature calcium phosphate structures was obtained during 3D powder printing. Furthermore polymer modification with hydroxypropylmethylcellulose (HPMC) or chitosan hydrochloride (ChitHCl) allowed the release profile to be retarded from first to zero order. Vancomycin, heparin and rhBMP-2 showed excellent compatibility with the printing process. Substantial retention of biological activity after printing and release from the bioceramic scaffolds was demonstrated.