A 1.8-mW, 18.5-mm2 64-channel current readout ASIC was implemented in 0.18-µm CMOS together with a new calibration scheme for silicon nanowire biosensor arrays. The ASIC consists of 64 channels of dedicated readout and conditioning circuits which incorporate correlated double sampling scheme to reduce the effect of 1/f noise and offset from the analog front-end. The ASIC provides a 10-bit digital output with a sampling rate of 300 S/s whilst achieving a minimum resolution of 7 pArms. A new electrical calibration method was introduced to mitigate the issue of large variations in the nano-scale sensor device parameters and optimize the sensor sensitivity. The experimental results show that the proposed calibration technique improved the sensitivity by 2 to 10 times and reduced the variation between dataset by 9 times.
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机译：在0.18-μmCMOS中实现了1.8mW，18.5mm 2 64通道电流读出ASIC以及针对硅纳米线生物传感器阵列的新校准方案。 ASIC由64个通道的专用读出和调节电路组成，这些通道包含相关的双采样方案，以减少1 / f噪声的影响以及与模拟前端的偏移。 ASIC提供10位数字输出，采样速率为300 S / s，同时最低分辨率为7 pA rms 。引入了一种新的电校准方法，以缓解纳米级传感器设备参数的巨大变化问题并优化传感器灵敏度。实验结果表明，所提出的校准技术将灵敏度提高了2到10倍，并将数据集之间的差异减少了9倍。
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