This article presents a thermal biosensor to diagnose anemia without chemical treatments using temperature increases of red blood cells when hemoglobin molecules absorb photons of specific wavelengths and convert them to thermal energy. For measuring the temperature changes, a micro-scaled platinum resistance temperature detector was developed. We also designed and fabricated a thermostat system to maintain a constant ambient temperature (<±0.1°C). An 8.0W/cm2 diode pumped solid state (DPSS) continuous wave (CW) laser module with a wavelength of 532 nm was used to heat the red blood cells. Using this system, we successfully measured temperature variations of whole blood samples from 10 anemic patients and subsequently determined the concentration of hemoglobin. The method proposed in this paper requires significantly smaller quantities of whole blood (6µl), as compared with conventional methods (175µl), and allows instantaneous diagnosis (6 seconds) of anemia.
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机译：本文介绍了一种热生物传感器，当血红蛋白分子吸收特定波长的光子并将其转换为热能时，无需使用红细胞的温度升高即可进行化学治疗来诊断贫血。为了测量温度变化，开发了微型铂电阻温度检测器。我们还设计并制造了一个恒温器系统，以保持恒定的环境温度（<±0.1°C）。以波长为532 nm的8.0W / cm 2 二极管泵浦固态（DPSS）连续波（CW）激光模块加热红细胞。使用该系统，我们成功地测量了10名贫血患者的全血样品的温度变化，并随后确定了血红蛋白的浓度。与常规方法（175 µl）相比，本文提出的方法需要的全血量（6 µl）明显更少，并且可以即时诊断（6秒）贫血。
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