The preparation of ion-exchange nanofiber membranes and their application for drug delivery

摘要

The objective of this study was to prepare ion-exchange nanofiber membranes from electrospun polyacrylonitrile (PAN) non-woven mats through alkaline hydrolysis, to investigate the binding efficiency of the drug onto the nanofibers and the in vitro drug release profiles. Sodium salicylate was selected as the model drug. Scanning electronic microscopy images showed that the nanofibers had a smooth surface and a uniform structure both before and after the hydrolysis treatment. FT-IR results suggested that the main interaction between fibers and model drugs was electrovalent bonding. The in vitro dissolution tests indicated that the drug release profiles were improved by the ion-exchange nanofibers with a long release time period and a weakened initial burst release effects. All the results demonstrated that the alkaline hydrolysis of PAN nanofibers was useful for the possible applications of ion-exchange membranes as transdermal drug delivery systems or topical drug delivery systems.