We have recently reported micellar nanoparticles selfassembledfrom a biodegradable and amphiphiliccopolymer poly{N-methyldietheneamine sebacate)-co-[(cholesteryl oxocarbonylamido ethyl) methylbis(ethylene) ammonium bromide] sebacate} P(MDS-co-CES), which were able to deliver small molecular drugsand biomacromolecules such as genes and functionalproteins individually or simultaneously into various typesof cells. In this study, these cationic micellarnanoparticles were employed as carriers to co-deliverpaclitaxel and Herceptin for achieving targeted deliveryof paclitaxel to HER2-overexpressing human breastcancer cells, as well as enhancing cytotoxicity throughsynergistic activities. Cellular response to our treatmentapproach was dependent on the HER2 expression level.Targeting properties of the nanocomplexes was displayedthrough significantly higher cellular uptake andcytotoxicity of the nanocomplexes in HER2-overexpressing BT474 compared to HER2-negativeHEK293 cells.
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