Neighborhood search approaches to non-coplanar beam orientation optimization for total marrow irradiation using intensity modulated radiation therapy

摘要

We consider the beam orientation optimization (BOO) problem for total marrow irradiation (TMI) treatment planningusing intensity modulated radiation therapy (IMRT). Currently, IMRT is not widely used in TMI treatment delivery;furthermore, the impact of non-coplanar beam orientations is not known. We propose and implement two versions ofa neighborhood search algorithm which solve the BOO problem effectively when gantry angles and couch translationsare considered. Our work shows that the BOO problem for TMI cases can be solved in a clinically acceptable amountof time and leads to treatment plans that are more effective than the conventional approach to TMI.