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Methylated N-(4-N,N-dimethylaminobenzyl) Chitosan for a Novel Effective Gene Carrier

机译:甲基化的N-(4-N,N-二甲基氨基苄基)壳聚糖用于新型有效基因载体

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To improve the solubility and gene tranfection efficiency of chitosan, methylated N-(4-N,N-dimethyl aminobenzyl) chitosans (MDMB-CS) were synthesized. The morphological and physicochemical characteristics, and transfection efficiency of MDMB-CS/pDNA complexes at varying N:P ratios were studied. MDMB-CS showed a great potential for gene carrier with the high level of gene transfection efficiencies and the negligible cytotoxic in Huh 7 cells.
机译:为了提高壳聚糖的溶解度和基因转染效率,合成了甲基化的N-(4-N,N-二甲基氨基苄基)壳聚糖(MDMB-CS)。研究了不同N:P比的MDMB-CS / pDNA复合物的形态,理化特性和转染效率。 MDMB-CS在Huh 7细胞中具有高水平的基因转染效率和微不足道的细胞毒性,显示了巨大的基因载体潜力。

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