Telomerase Restrictors Might be A Novel Source for Screening Anti-HIV Agents

摘要

Objectives: to screen anti-HIV agents from telomerase restrictors(TRs); Method: Selection of the maximum concentration of telomerase restrictor with minimum toxicity by means of MTT proliferation determination, and screening of anti-HIV agents by means of determining CEM-GFP fluorescence with FACS and through INNOTEST P24 HIV Antigen mAb ELISA. Results: Two telomerase restrictors were demonstrated to effectively restrict the proliferation of HIV. Conclusion: Telomerase restrictors(TR) might be the source for screening anti-HIV agents.