Biodistribution of 14C poly(butyl cyanoacrylate) nanoparticles after I.v. administrationto glioblastoma bearing rats

摘要

Previous results have shown that polysorbate80 coated poly(butyl cyanoacrylate) nanoparticlesenabled a significant transport of a number of drugsinto the brain across the blood-brain-barrier (BBB)after I.v. administration to rats. In the present study,a comparative body distribution study of nanoparticles,polysorbate 80-coated nanoparticles anddoxorubicin-loaded nanoparticles in tumor-bearingrats was performed.Attention was particularly focused on the biodistributionof nanoparticles into the brain and into a ratglioblastoma (101/8).