Brain Uptake of Nanoparticle-Bound Drugs Enabled by Apolipoprotein E

机译：载脂蛋白E使大脑吸收纳米颗粒结合药物

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Nanoparticles with apolipoprotein E (apo E) covalentlybound to the surface of albumin, loaded withloperamide achieved a significant, anti-nociceptiveresponse in mice after I.v. injection. This clearlydemonstrates that binding of apolipoprotein E to thenanoparticles facilitates transport of drugs acrossthe blood-brain barrier (BBB).

机译：载脂蛋白E（apo E）共价的纳米颗粒结合到白蛋白的表面，载有洛哌丁胺具有显着的抗伤害感受性静脉注射后小鼠的反应注射。这很明显证明载脂蛋白E与纳米颗粒有助于药物跨界运输血脑屏障（BBB）。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Kerstin Michaelis; J?rg Kreuter; Renad Alyautdin; Elisabeth Herbert; Klaus Langer;
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中图分类药学;
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专利

1. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. [J] . Kreuter J, Shamenkov D, Petrov V, Journal of drug targeting . 2002,第4期

机译：载脂蛋白介导的结合纳米颗粒的药物跨血脑屏障的运输。
2. Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain [J] . Kreuter J, Hekmatara T, Dreis S, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2007,第1期

机译：载脂蛋白A-I和载脂蛋白B-100与白蛋白纳米颗粒的共价结合使药物能够转运到大脑
3. Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries. [J] . Hulsermann U, Hoffmann MM, Massing U Journal of drug targeting . 2009,第8期

机译：培养的脑微血管内皮细胞和完整的脑毛细血管摄取载脂蛋白E片段偶联的脂质体。
4. APOLIPOPROTEIN-MEDIATED TRANSPORT OF NANOPARTICLE-BOUND DRUGS ACROSS THE BLOOD-BRAIN BARRIER [C] . J. Kreuter, D. Shamenkov, V. Petrov, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：载脂蛋白介导的纳米颗粒结合药物跨血脑屏障的转运
5. THEORY OF INTERACTION OF DRUGS AND OTHER MOLECULAR SPECIES WITH BLOOD-BRAIN BARRIER AND EVALUATION OF BRAIN-UPTAKE INDEX INCLUDING COOPERATIVE EFFECTS AND PHASE-TRANSITION [D] . VIMAL, RAM LAKHAN PANDEY 1983

机译：药物与其他分子与血脑屏障相互作用的理论以及包括协同效应和相变的脑吸收指数的评估
6. Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer’s disease brain [O] . Julia E Love, Ryan J Day, Justin W Gause, 1955

机译：核摄取载脂蛋白E4的氨基末端片段可促进细胞死亡并位于阿尔茨海默氏病大脑的小胶质细胞内
7. Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood–Brain Barrier Disruption after Controlled Cortical Impact in Mice: An 18F-Fluorodeoxyglucose PET/CT Study [O] . Xinghu Qin, Hong You, Fang Cao, 2017

机译：载脂蛋白E模拟肽通过降低小鼠控制皮质冲击后的血脑屏障破坏来增加脑葡萄糖吸收：18氟氟氧氧糖PET / CT研究

Brain Uptake of Nanoparticle-Bound Drugs Enabled by Apolipoprotein E

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