ALGINATE-MAGNESIUM ALUMINUM SILICATE COMPOSITE FILMS FORMODIFYING RELEASE OF PROPRANOLOL TABLETS

摘要

Composite films prepared from the mixture ofsodium alginate and magnesium aluminum silicateshowed a lower permeability and a longer lag time forpropranolol HCl. The tablets coated with LVSA film gavea higher release of propranolol HCl, due to a pinholing ofthe film, while those coated with composite films showeda good film integrity. This suggested that alginatemagnesiumaluminum silicate composite film can be usedas a coating material for modifying the release of drugfrom the tablets.