Estimation of Optimal Treatment Protocol of Methotrexate Administered by Controlled ReleaseImplant for Intraocular Lymphoma

摘要

The optimal treatment protocol of MTX for IOLby implant was estimated from a clinical perspective. Theretinal permeability of MTX was calculated to be9.25×10-6cm/s for rabbit and 9.09×10-6cm/s for human bycomparing with in vivo data. The therapeutic release ratewas calculated to be in the range from 0.35 to 2.8μg/hr.