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SUSTAINED RELEASE OF PEGYLATED MONOCLONAL ANTIBODY FRAGMENTS FROM DRUG DELIVERY SYSTEMS

机译：药物递送系统中乙二醇化单克隆抗体片段的持续释放

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It is feasible to deliver PEGylated antibody fragments (Fab) against VEGF by sustained release delivery systems which include PLGA microspheres and PLAD. Optimization work is required to reduce the initial release and aggregation for the PLGA microspheres. Animal studies are required to evaluate the vivo efficacy of administering the PEGylated Fab using these delivery systems.

机译：通过包括PLGA微球和PLAD的持续释放递送系统递送针对VEGF的聚乙二醇化抗体片段（Fab）是可行的。需要进行优化工作以减少PLGA微球的初始释放和聚集。需要进行动物研究以评估使用这些递送系统施用PEG化Fab的体内功效。

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society 》|2002年|p.62-63|共2页
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Xanthe M. Lam; Hak-Kim Chan; Tue H. Nguyen; Jeffrey L. Cleland;
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中图分类化学工业 ;
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4. SUSTAINED RELEASE OF PEGYLATED MONOCLONAL ANTIBODY FRAGMENTS FROM DRUG DELIVERY SYSTEMS [C] . Xanthe M. Lam, Hak-Kim Chan, Tue H. Nguyen, Annual meeting of the Controlled Release Society . 2002

机译：从药物递送系统中持续释放聚乙二醇化单克隆抗体片段
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SUSTAINED RELEASE OF PEGYLATED MONOCLONAL ANTIBODY FRAGMENTS FROM DRUG DELIVERY SYSTEMS

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