ACCELERATED CLEARANCE OF THE SECOND DOSE OF STERICALLY STABILIZED LIPOSOMES (SL) IN RATS: HISTOPATHOLOGICAL AND HEMATOLOGICAL STUDIES

摘要

The first dose of SL did not cause liver inflammation and did not affect the density of Kupffer cells in the liver. The titer of complement system was constant even after injection of the second dose of SL. These results suggest that the increased hepatic uptake of the second dose of SL, observed in the early studies, did not result from the increased density of Kupffer cells as well as activation of the complement system.