Dosimetry modeling of inhaled particles

摘要

A one dimensional model for describing the transport and fate of inhaled particles and gases in the human respiratory tract has been developed. The architecture of the human lung is described using the Weibel's model with regularized dichotomy. The aerosol General Dynamic Equation is solved numerically during inhalation using a discrete-nodal point method for describing the particle size distribution. In the model the mechanisms of nucleation, condensation, coagulation, convection and deposition of gases and particles and a module for considering gas phase reactions have been included. Boundary layer effects are incorporated in the model by introducing appropriate dimensionless numbers (Nusslet, Sherwood) in the estimation of the thickness of the corresponding boundary layer. The model predicts the evolution of the size distribution and composition of inhaled particles and their deposition characteristics for each generation of the human air-ways.