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Testing Overview of The Speclalty Acrylate/Methacrylate (SAM) Panel

机译:专业丙烯酸酯/甲基丙烯酸酯(SAM)面板的测试概述

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The Specialty Acrylates and Methacrylates Panel ("SAM") was formed at the Chemical Manufacturers Association in March 1987 to address concerns raised by EPA on both existing and new specialty acrylates and methacrylates. Membership in the pnael is open to all producers, importers, formulators and users ofthese chemicals. The purpose of the SAM Panel is two-fold: to remove the restrictions on innovation caused by EPA's regulatory position on new SAM chemicals under TSCA Section 5; and to avoid or modify EPA's mandatory testing requirements on SAM chemicals under TSCA Section 4. On June 19, 1989, SAM and EPA reached agreement on a research and regulatory program. Under this program SAM conducted toxicity screening tests to better understand the structure activity relationships between acrylate and methacry-late subcategories and possible carcinogenic effects. In return, EPA did not proceed with a TSCA Section 4 Test Rule. In addition, if the bioassay on the methacrylate shows no evidence of cancer, EPA may eliminate all concern over potential carcinogenicity of methacrylates.
机译:1987年3月,由化学品制造商协会成立了特种丙烯酸酯和甲基丙烯酸酯小组(“ SAM”),以解决EPA对现有和新型特种丙烯酸酯和甲基丙烯酸酯提出的关注。这些化学品的所有生产商,进口商,配方商和用户都可以使用天然橡胶的会员资格。 SAM专家组的目的有两个:消除由于TSCA第5节中EPA对新SAM化学品的监管地位而对创新造成的限制;以及避免或修改EPA根据TSCA第4节对SAM化学药品的强制性测试要求。1989年6月19日,SAM和EPA就研究和监管计划达成协议。在该计划下,SAM进行了毒性筛选测试,以更好地了解丙烯酸酯和甲基丙烯酸酯亚类之间的结构活性关系以及可能的致癌作用。作为回报,EPA没有继续执行TSCA第4节“测试规则”。此外,如果对甲基丙烯酸酯的生物测定没有证据表明存在癌症,EPA可能会消除对甲基丙烯酸酯潜在致癌性的所有担忧。

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