Iron oxide nanoparticles conjugated with trastuzumab as an immunospecific probe for detecting HER2 antigen

摘要

In this study we synthesized dextran coated iron oxide nanoparticles conjugated to trastuzumab (anti -HER2) and checked it for detecting HER2 antigen in 5 cancerous cell lines with colorimetric methods. The results suggest that the trastuzumab conjugated to iron oxide nanoparticles may be considered for further investigation as an alternative test for checking the HER2 expression level of cancer cells. The complex can provide the possibility of in vivo imaging of the tumors using magnetic resonance imaging (MRI).