High-Resolution Transesophageal Right Ventricular Far Field Potential and Left Ventricular Potential in Heart Failure Patients with Left Bundle Branch Block

摘要

Cardiac resynchronisation therapy (CRT) by biventricular (BV) pacing is an established therapy for heart failure (HF) patients with interventricular delay (IVD), but not all patients improved clinically. The aim of the study was to evaluate directed transesophageal signal averaged electrocar-diography (SAECG) for recording of right ventricular (RV) far field potential and left ventricular (LV) potential in evaluation of IVD and LV delay (LVD) in patients with HF and left bundle branch block (LBBB).Methods: Ten HF patients (age 69 ± 10 years; 2 females, 8 males) in NYHA class 3, 27 ± 5 % LV ejection fraction and 167 ± 20 ms QRS duration (QRSD) were analyzed IVD and LVD using directed transesophageal bipolar recording of the posterior LV wall potential with hemispherical electrodes before implantation with devices for CRT. IVD was the interval between onset of RV potential and onset of LV potential in the transesophageal SAECG. LVD was the interval between onset and offset of LV potential in the transesophageal SAECG.Results: Recording of directed transesophageal signal averaged RV and LV potential was possible in 100% of HF patients with LBBB. Transesophageal IVD was not different than transesophageal LVD (85 ± 18 ms vs. 71 ± 20 ms, P = 0.190). Transesophageal IVD and LVD were smaller than QRSD (P < 0.001). Transesophageal IVD was not different than intracar-diac RV-LV-interval between BV pacing device electrodes (85 ± 18 ms vs. 69 ± 26 ms, P = 0.144). Finite element simulation evaluated electrical cardiac pacing field.Conclusion: Directed transesophageal LV and RV far field SAECG may detect IVD and LVD in symptomatic HF patients with LBBB before implantation of BV pacing device. High-resolution transesophageal SAECG recording may be a useful non-invasive technique to evaluate RV and LV desynchronisa-tion in HF patients.