Bioluminescence Tomography Based on Bilateral Weight Laplace method for In vivo Morphological Imaging of Glioma

摘要

The development of Bioluminescence Tomography (BLT) has allowed the quantitative three dimension (3D) whole bodyimaging and non-invasive study of biological behavior of cancer. However, the ill-posed problem of BLT reconstructionlimits the quality of reconstruction result. In this work, we proposed a Bilateral Weight Laplace (BWL) method thatutilizes a non-local Laplace regularization to improve the imaging quality of bioluminescence tomography reconstruction.The non-local Laplace regularization was constructed by spatial weight and range weight to penalize theneighborhood-variance of reconstructed source density in both spatial and range domain. To evaluate the performance ofBWL method, both dual-source BLT reconstruction experiment in simulation data and in vivo BLT reconstruction inorthotopic glioma mouse model were designed. Furthermore, fast iterative shrinkage/threshold (FIST) method andLaplace method were utilized to compare with BWL. Both dual-source experiment and in vivo experiment demonstratethat the construction results of BWL method provide more accurate tumor position (BCE = 0.37mm in dual-sourceexperiment) and better tumor morphological information.