CLEANROOM AND BIOCONTAINMENT

摘要

In a cleanroom where bilogical agent are handled the control of contamination has the doublernmeaning of minimising the airborne contamination within the cleanroom and avoiding the leakagernoutside the facility of any biological agent.rnThe existing standards for the pharmaceutical industries, the GMP, define the characteristicsrnof a cleanroom for the production of sterile product, with non indication for the biocontainemt. Thernstandard for the biocontainment, NIH standard, do not state anything about the indoor air quality.rnThe Engineer involved in the design of a biocontained cleanroom have to identify the technicalrnsolution that satisfy both the control of airborne contamination and containment of the facility. Anrnimportant role is played by the room pressure cascade and relevant control system; the otherrnimportant criteria is HEPA air filtration, on the supply and on the exhaust. The ventilation systemrnhave to ensure the internal condition overcoming the mechanical and electrical failure: that is whyrnfor some installation it has been foreseen a redundancy on the exhaust fan.rnAs a conclusion an HVAC flow diagram for a biocontained cleanroom is presented where therntechnical solutions discussed are shown.