Abstract: The goal of interstitial laser therapy is to destroyneoplastic tissue through localized heating.Temperature elevations to the necrotic coagulationthreshold of about 60$DGR@C cause the induction ofirreversible, as well as, reversible alterations totissues. While chronic effects prevail days followingthe treatment, the relevant issue from the perspectiveof magnetic resonance imaging-monitoring of lasertherapy, is the ability of MRI in detecting theseeffects. In this study time-course MRI images of rabbitmusculature, treated with 'temperature controlled'Nd:YAG laser irradiation were correlated withhistological changes. The MRI appearance of theinterstitial laser lesion can be divided into threecategories of acute, sub- acute, and chronic. Thedynamics of chronic lesion development, includingvariations in shape, size and composition of the lesionwere successfully documented by T2-weighted spin echoMRI.!8
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