The U.S. EPA Activities and Information Systems Used for Chemical Exposure Screening, Modelling and Prioritisation and Risk-Based Decision Making: Needs, Challenges and Opportunities for Data Sharing and Interoperability of Tools on Global Scale Including

摘要

Within the US EPA Office of Research and Development's (ORD's) Chemicals for Safety and Sustainability (CSS) research program, efforts are underway to provide information that is useful for the risk-based prioritization of thousands of chemicals, particularly those found in consumer products. The information has been made publicly available through ORD's CompTox Chemistry Dashboard (https://comptox.epa.gov). In this presentation the research efforts that contribute to the collection and curation of consumer product formulations, article compositions and ingredient uses will be discussed. This information is obtained through both automated collection techniques from manufacturer-supplied documents and measurement of chemicals via suspect screening analysis. Finally, predictions from ORD-developed models for such values as physicochemical properties, functional use, product composition, and chemical exposure, which are provided via the Chemistry Dashboard, will be discussed. The views expressed in this abstract are those of the authors and do not necessarily reflect the views or policies of the US Environmental Agency.