SOLUBILITY OF FLURBIPROFEN AND TIMOLOL MALEATE IN DENSE CARBON DIOXIDE

摘要

Equilibrium solubilities in supercritical, carbon .dioxide of bioactive compounds flurbiprofen and timolol maleate were measured by a static analytical method from 10 up to 26 MPa at 313K.. Solubility data were correlated using Chrastil's empirical density-based model. The effect of adding ethanol, as a cosolvent, was also investigated, at 313 K and 19 MPa for timolol maleate, and at 313 K and 20 MPa for flurbiprofen. For both compounds, solubility is enhanced with an increasing amount of cosolvent added.