Practical Implementation of DNA Computations

摘要

Several theoretical models of DNA computation have been proposed since Adleman's original experiment, but there has been a shortage of empirical results in the literature. In this paper we describe preliminary investigations into the laboratory implementation of one existing model, the parallel filtering model. We describe the lessons to be drawn from such experiments, and show how techniques such as PCR and affinity purification may be replaced by more error-resistant alternatives. We also describe one possible solution to the problem of solution read-out.