Use of batch control technique in unseeded batch cooling crystallization

摘要

A batch control technique called BMPC (batch model predictive control) has been used for reproducible generation of seed crystals in an unseeded batch cooling crystallization process. In unseeded crystallization, the seed generation through primary nucleation is the most critical step and it is necessary to find an optimum cooling profile that gives an appropriate number of seed crystals. However, the heat evolved during the nucleation makes temperature control difficult. To overcome this problem, BMPC has been introduced and successfully employed.