A Customized Dot Plot Analysis for Alpha Satellite DNA Localization

摘要

Numerical representation of genomic signals is very important as many of the methods for detecting repeated sequences are part of the digital signal processing field. An original nucleotide sequence representation and a mapping algorithm are used to provide a single numerical sequence for DNA repeats detection which includes information about re peats length. A customized dot plot analysis was used to esti mate position of repeats, using two methods of estimating similarity between numerical subsequences. These approaches were combined to isolate position and length of DNA repeats from human alpha satellite DNA.