Electrospinning Micro- to Nano-fibrous Natural and Synthetic Biomedical Textiles

摘要

The composition (i.e. biomaterials of synthetic or natural origin) and structure (or design) of a biomedical textile dictate the resulting cell-environment interactions of the textile. Scientists involved in the fabrication of biomedical textiles, for such applications as tissue engineering scaffolds, have turned to nanotechnology and the development of nanofibers as solutions mimicking the geometry of the sub-micron diameter fibers of the native extracellular matrix (ECM) (diameters on the order of 50 to 500 nm). Electrospinning has evolved as a processing technique that allows the fabrication of nano-fibrous textiles. This review will discuss electrospinning as the primary technology available to create biomedical textiles, specifically tissue-engineering scaffolds, that are capable of mimicking native tissue structures.