Designing an Interactive Device to Slow Progression of Alzheimer's Disease

摘要

Inactive sedentary working styles result in many people exercising insufficiently, leading to poor blood circulation and decreased blood flow of the brain. Consequently, amyloid beta (Aβ) accumulates in the brain, impairing nerve conduction and potentially causing nervous necrosis, both of which cause Alzheimer's disease (AD). The early symptoms of Alzheimer's disease include inability to recognize orientation in space and memory decline, along with amyotrophic Hippocampus, and low Neurotrophic content and Cerebral blood flow. Brain-derived neurotrophic factor (BDNF) is a crucial component for brain nerve growth, abundant BDNF alleviates nervous necrosis. An environment with BDNF secretion is directly proportional to cerebral blood flow. Research has indicated that engaging in puzzle games and finger motor exercises can mitigate and ameliorate Alzheimer's disease. Performing tasks with the fingers make extensive use of the brain's motor and somatosensory cortices, thus promoting activity and increased blood flow in the brain to generate more BDNF facilitating brain neuron growth. The goal of this research is to increase cerebral circulation, through patient-oriented activity, to elucidate which activities increase cerebral circulation, and sustained local motion enhancing muscle contraction that increases blood flow velocity. These three game guidelines are devised to improve spatial cognition and increase cerebral circulation.