Efficient Synthesis Of Enaminones And Cyclic Imides Using Ammonium Acetate Under Microwave Conditions

摘要

Enaminones are versatile intermediates for the synthesis of many natural and pharmaceutical compounds. We have developed an efficient method for their synthesis under microwave irradiation. A number of these enaminones were synthesized in 73-91% yields within few minutes from 1,3-diones and ammonium acetate. Further, reactions of the enaminones with anhydrides under microwave conditions resulted in the formation of enone-imides in very good yields. The process is simple, quick, and high yielding. Cyclic Imides were also obtained in high yields under similar conditions, upon reactions of ammonium acetate with various anhydrides. A library of the cyclic imides was synthesized; the process was applied for the synthesis of thalidomide analogues.