Effects of VEGF on adhesion of mammary carcinoma cells to brain microvascular endothelium

摘要

for the ß4 mutant. Pretreatment of the cancer cells with ¿6, ß1, ¿5 integrin antibodies and pretreatment of the cell monolayer with laminin-5 antibody significantly decreased the adhesion of WT and 1355T. Our results suggest that ¿6ß4, ¿6ß1, ¿5ß1 and their ligand, laminin-5, play a role in breast tumor cell adhesion, and that VEGF enhances the adhesion by compromising the integrity of bEnd3 monolayer.