From Networks to Systems to Complex Systems: A Signaling Pathway Coordination Case Study

摘要

Networks of Signaling pathways provide a robust mechanism for cells to respond to various biological stimuli. In this paper we demonstrate cell adaptation through the viewpoint of an organizing principle between two interconnected pathways- MAPK and PKC. We use a multi-layered system representation of the pathways to determine the pathway components contributing to the adaptive behavior and coordination. The adaptation can be thought of as being manifested by a change in parameters of the coordinator. In silico experiments are conducted using MAPK/PKC mathematical model in literature to investigate the role of PLA