Peptide-Polysaccharide Based Injectable Hydrogel for Sustained Delivery of Active Agents

摘要

A Fmoc-Phe-Phe-OH hydrogel was prepared by self assembly of peptides alone and in presence of alginate. Alginate incorporation improved the mechanical integrity and stability respect to peptide only gel structure. The sustained release time of vancomycin also was found to be prolonged by managing incorporated alginate amount. The resulting peptide-polysaccharide composite gel system is a promising material for injectable and biodegradable hydrogel.