Fibrin-Hyaluronic Acid Interpenetrating Network Hydrogel with Improved Fibrin Stability

摘要

Fibrin-HA IPN hydrogels were formed through thrombin-induced polymerization of fibrin monomers and disulfide cross-linked hyaluronic acid and showed improved stability over analogous fibrin hydrogel while retaining the ability to support proliferation of encapsulated osteoblasts as pure fibrin hydrogel did. The result suggests that fibrin-HA IPN hydrogel is a potential scaffold in tissue engineering application.