Bone Nodule Formation by Osteoblast-Like Cells Incubated with a Novel Silane Modification of Glass

摘要

Enrichment of a substrate surface with -NH_2 modifications is a valid tool for producing cell contacting materials that are osteoconductive. In order to enhance the osteogenic nature of these substrates and control the subtle switches from osteoblast to osteocyte and develop materials that induce matrix remodelling, we must combine changes in surface chemistry with a controlled nanotopography.